Submitted: 09 Feb 2017
Revised: 20 May 2017
Accepted: 03 Jun 2017
First published online: 14 Jun 2017
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Int J Enteric Pathog. 2017;5(3):76-79.
doi: 10.15171/ijep.2017.18
  Abstract View: 1691
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Original Article

Sumac (Rhus coriaria L.) Represents a Considerable Antibacterial Activity Against Meticillin Susceptible and Meticillin Resistant Staphylococcus aureus

Mohammad Mahdi Ahmadian-Attari 1, Meysam Khanlarbeik 2, Mohammad Reza Fazeli 2 * , Hossein Jamalifar 2 *

1 Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
2 Department of Drug and Food Control and Pharmaceutical Quality Assurance Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Staphylococcus aureus is one of the most important pathogens and the cause of suppuration, abscess formation, a variety of pyogenic infections, and even fatal septicemia in human beings. Isolation of resistant strains of S. aureus especially meticillin-resistant one has elucidated the importance of finding new antibacterial agents. Sumac is one of the important medicinal herbs of Iranian traditional medicine (ITM). Sumac has been traditionally prescribed for some ailments with infectious etiology and therefore, it probably contains antibacterial compounds. Recently, antibacterial activities of sumac against some bacteria were studied by our team.

Objective: In this article, we aimed to compare the antibacterial activities of sumac against meticillin susceptible (MSSA) and meticillin resistant S. aureus (MRSA) via minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determination.

Materials and Methods: Antibacterial activity of sumac water extract was studied on 19 clinical and 1 standard strain of S. aureus via MIC and MBC determination. Based on their sensitivity to cloxacillin, these bacteria were classified as meticillin-susceptible, intermediate meticillin-resistant, and meticillin-resistant. MICs and MBCs of the extracts in these 3 groups were statistically compared via one-way analysis of variance (ANOVA) followed by a post hoc analysis (Tukey HSD test) using SPSS for Windows (version 15).

Results: The results showed that in spite of different susceptibilities to cloxacillin, susceptibility to sumac extract was not different and MICs and MBCs of sumac for all clinical isolates including MSSA and MRSA were similar (P > 0.05).

Conclusion: Based on previous studies, sumac extract acts against S. aureus probably through changing the cell wall properties. This activity is similar for both MRSA and MSSA. More investigation on the precise mechanism of action of this extract would be fruitful.

Copyright © 2017 The Author(s); Published by Alborz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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