Submitted: 18 Oct 2016
Revised: 11 Jan 2017
Accepted: 10 Feb 2017
First published online: 15 Feb 2017
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Int J Enteric Pathog. 2017;5(1):18-23.
doi: 10.15171/ijep.2017.05
  Abstract View: 2056
  PDF Download: 1299
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Research Article

Evaluation of Reciprocal Pharmaceutical Effects and Antibacterial Activity of Silver Nanoparticles and Methanolic Extract of Crocus sativus L. (Saffron) on Some Bacterial Strains

Anahita Samiee Zafarghandi 1, Hamid Reza Ahmadi Ashtiani 2 * , Seyyed Mahdi Rezayat 3, Neda Soleimani 4, Seyyed Reza Hosseini Doost 5, Shabnam Heydarzadeh Khoyi 1

1 MSc Student in Microbiology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
2 PhD in Clinical Biochemistry, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
3 Professur of Pharmacology & Toxicology, Department of Pharmacology, School of Medicine, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
4 Assistant Professor, Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
5 Professur of Microbiology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
*Corresponding Author: Hamid Reza Ahmadi Ashtiani; PhD in Clinical biochemistry, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran. Email: hamidr.ahmadi@yahoo.com

Abstract

Background: Silver nanoparticles (Ag-NPs) are the most prominent nanoparticles which are recognized for their high antimicrobial efficacy.
Objectives: The aim of this study was to evaluate the reciprocal pharmaceutical effects and antibacterial activity of Ag-NPs and methanolic extract of Crocus sativus L. (saffron) on some bacterial strains.
Materials and Methods: For evaluation of antibacterial activity of Ag-NPs and methanolic extract of C. sativus L. (saffron) on some bacteria, agar well diffusion method was used. Minimal inhibition concentration (MIC) and minimum bactericidal concentration (MBC) were determined for saffron extract, Ag-NPs, and their combination on methicillin-resistant Staphylococcus aureus (MRSA) and S. pyogenes and S. epidermidis.
Results: The combination of medium concentrations of Ag-NPs (500 μg/mL) and saffron extract (50 mg/mL) was in the optimum mode to eliminate S. epidermidis and S. pyogenes. The results showed that saffron extract, Ag-NPs, and their combined form had antibacterial effects on these bacteria.
Conclusion: It is suggested to evaluate the synergistic effects of active components of the extract and antimicrobial preservatives used in food, health, pharmaceutical, and cosmetic industries.
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