Submitted: 06 Jan 2014
Revised: 05 Feb 2014
Accepted: 10 Feb 2014
First published online: 05 Oct 2016
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Int J Enteric Pathog. 2014;2(2): e17426.
doi: 10.17795/ijep17426
  Abstract View: 1212
  PDF Download: 790

Research Article

Characterization of Partially Purified Bacteriocin Like Substance (BLIS) Produced by Probiotic Lactobacillus Strains

Saeed Ismail Khanian 1, Naheed Mojgani 2 *

1 Department of Animal Science, Isfahan Center for Research of Agricultural Science and Natural Resources, Isfahan, IR Iran
2 Biotechnology Department, Razi Vaccine and Serum Research Institute, Karaj, IR Iran
*Corresponding author: Naheed Mojgani, Biotechnology Department, Razi Vaccine and Serum Research Institute, Karaj, IR Iran. Tel.: +98-264570038, Fax: +98-264570038, Email:


Background: There is an increasing interest in search for antimicrobial peptides (bacteriocins and bacteriocin-like compounds) produced by lactic acid bacteria (LAB) because of their potential to be used as antimicrobial agents for improving the safety of food products.

Objectives: The main objective of study was to evaluate the antibacterial potential of locally isolated Lactic Acid bacteria (LAB) and determine their bacteriocin producing ability in in-vitro conditions.

Materials and Methods: The antibacterial activity of 77 isolated LAB strains was tested against a number of pathogens by well-diffusion method. The isolates demonstrating antimicrobial potential were selected and tested for the production of bacteriocin or bacteriocin like substance. The bacteriocin produced by two of the isolates were partially purified and characterized.


Implication for health policy/practice/research/medical education:

A number of Probiotic Lactic Acid Bacteria Produce bacteriocins which could be used in pharmaceutical industry as an alternative to antibiotics and in food industry as an alternative to chemical preservatives.

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