Submitted: 02 Dec 2019
Revised: 18 Feb 2020
Accepted: 23 Feb 2020
First published online: 28 Feb 2020
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Int J Enteric Pathog. 2020;8(1):15-18.
doi: 10.34172/ijep.2020.04
  Abstract View: 241
  PDF Download: 221

Original Article

Frequency and Antibiotic Susceptibility of Pseudomonas aeruginosa and Acinetobacter baumannii Infections in Pediatrics Intensive Care Unit of Imam Ali Hospital, Karaj, Iran During 2017- 2018

Reza Arjmand 1 ORCiD, Kumars Porrostami 1, Seyedeh Sana Esteghamat 2, Pouria Chaghamirzayi 2 ORCiD, Parastoo Sharifian 3, Ehsan Zahmatkesh 1, Saeed Nikkhah 1, Mostafa Qorbani 4,5, Omid Safari 1 *

1 Department of Pediatrics, Imam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran
2 Alborz University of Medical Sciences, Karaj, Iran
3 Department of Microbiology and Immunology, Medical School, Alborz University of Medical Sciences, Karaj, Iran
4 Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
5 Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Omid Safari, Department of Pediatrics, Imam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran, Email: Email: omidsafari50@gmail.com

Abstract

Background: Pseudomonas aeruginosa and Acinetobacter baumannii are widely ubiquitous in nature. In addition, they are opportunistic pathogens for humans and the common cause of nosocomial infections.

Objective: Due to the increased antibiotic resistance in the treatment of nosocomial infections, this study aimed to evaluate the antibiotic susceptibility pattern of P. aeruginosa and A. baumannii in the pediatrics intensive care unit (PICU).

Materials and Methods: Totally, 280 clinical samples from PICU patients were evaluated in this study. The samples were examined for P. aeruginosa and A. baumannii using standard microbiological methods. Finally, the Epsilometer test method was performed to investigate the antibiotic susceptibility pattern of these bacteria.

Results: The results revealed a total of 21 isolates (7.5%) of P. aeruginosa and 11 isolates (3.9%) of A. baumannii. P. aeruginosa isolates showed the highest susceptibility to colistin (85.7%) and gentamicin (66.7%) while A. baumannii isolates were more susceptible to colistin (100%), ceftazidime (54.5%), and amikacin (45.5%), respectively.

Conclusion: Due to the antibiotic susceptibility patterns of bacterial isolates in the recent study, colistin and gentamicin are recommended for the treatment of P. aeruginosa infections and colistin, ceftazidime, and amikacin are suggested for A. baumannii infections.

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