Submitted: 29 Sep 2018
Revised: 18 Feb 2019
Accepted: 04 Mar 2019
First published online: 11 Mar 2019
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Int J Enteric Pathog. 2019;7(2):49-54.
doi: 10.15171/ijep.2019.12
  Abstract View: 50
  PDF Download: 65

Original Article

Determination of Antimicrobial Resistance Patterns in Bloodstream Infections-Isolated Bacteria From a University Tertiary Hospital Patients

Alka Hasani 1,2, Nasim Asadi Faezi 2, Mohammad Ahangarzadeh Rezaee 1, Elham Sheykhsaran 2, Narges Darabi 3, Hamed Ebrahimzadeh Leylabadlo 4,5 * ORCiD

1 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Microbiology Department, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
4 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5 Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Hamed Ebrahimzadeh Leylabadlo, Tel: +989147384585; Email: hamedebr7@gmail.com

Abstract

Background: Bloodstream infections are considered a significant medical concern associated with high morbidity and mortality rates. Therefore, physicians should be guided to use antimicrobial susceptibility patterns in order to select appropriate empiric antimicrobial agents to treat the patients who suffer from bacteremia.

Objective: The present study aimed to determine antimicrobial resistance and susceptibility patterns in isolates collected from bloodstream infections. Materials and Methods: To achieve this, a total of 710 bacterial blood culture isolates were collected from Sina hospital, and then susceptibility patterns to a number of antibiotics were analyzed according to Clinical and Laboratory Standards Institute guidelines.

Results: The identified isolates included Staphylococcus aureus 14 (20.6%), Escherichia coli 14 (20.6%), Acinetobacter baumannii 12 (17.6%), Pseudomonas aeruginosa 11 (16.2%), Coagulasenegative Staphylococcus 8 (11.8%), Klebsiella pneumoniae 6 (8.8%), and Enterobacter spp. 3 (4.4%). The total resistance rate to co-trimoxazole, ceftriaxone, ceftazidime, cefotaxime, ofloxacin, gentamicin, ciprofloxacin, levofloxacin, amikacin, and imipenem was 44 (64.7%), 42 (61.8%), 39 (57.4%), 38 (55.9%), 35 (51.51%), 32 (47.1%), 31 (45.6%), 25 (36.8%), and 27 (39.7%), respectively. Finally, the susceptibility rate to amikacin and imipenem was 43 (63.2%) and 41 (60.3%), respectively.

Conclusion: In general, A. baumannii strains isolated from blood cultures were resistant to most antibiotics and the greatest sensitivity was observed to gentamicin (58.3%) compared to other antibiotics. Therefore, gentamicin was found as the most effective antibiotic for treating bloodstream infections caused by A. baumannii.

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