Submitted: 10 May 2015
Revised: 27 May 2015
Accepted: 09 Jun 2015
First published online: 06 Oct 2016
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Int J Enteric Pathog. 2015;3(4): e29796.
doi: 10.17795/ijep29796
  Abstract View: 598
  PDF Download: 375

Brief Report

Proportion of Helicobacter pylori Among Dyspeptic Patients Detected by Molecular Methods in a Teaching Hospital in Sri Lanka

D.L. Nushka L. Ubhayawardana 1, Manjula M. Weerasekera 1, Deepaka D. Weerasekera 2, T.D.Chinthika P. Gunasekera 1, S.S. Neluka Fernando 1 *

1 Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
2 Department of Surgery, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
*Corresponding author: S.S. Neluka Fernando, Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. Tel: No: +94-718016290, Fax: +94-112802026, Email: fneluka@sjp.ac.lk

Abstract

Background: Infection with Helicobacter pylori is considered as a major cause of chronic gastritis, peptic ulcer disease and gastric cancer. More than half of the world’s population is infected with H. pylori. In Sri Lanka various groups have reported a prevalence ranging from 3% to 70% over the last decade.

Objectives: The aim of this study was to determine the current proportion of H. pylori and risk factors for H. pylori infections.

Patients and Methods: The study was a cross sectional, descriptive study in which 100 dyspeptic patients who were required to undergo endoscopy examination were included. The study was carried out at a Teaching Hospital in Sri Lanka. In-house urease test and PCR amplification of the glmM gene of H. pylori was performed to diagnose H. pylori infection. A questionnaire was filled to collect sociodemographic data from the dyspeptic patients.

Results: Eighteen dyspeptic patients were positive for H. pylori by both in-house CLO (Campylobacter-like organism test) test and polymerase chain reaction (PCR). Ten of cases were male (18%) while eight were female (17%). There was no association between the demographic factors and risk of H. pylori infection.

Conclusions: The proportion of H. pylori infections was found to be 18% in the study population. There was no significant association with H. pylori and the studied demographic factors.

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