Submitted: 24 Nov 2013
Revised: 08 Dec 2013
Accepted: 16 Dec 2013
First published online: 05 Oct 2016
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Int J Enteric Pathog. 2014;2(2): e16349.
doi: 10.17795/ijep16349
  Abstract View: 901
  PDF Download: 553

Research Article

Antibacterial Activity of Essential Oil of Sature jahortensis Against Multi-DrugResistant Bacteria

Saeide Saeidi 1, Yasub Shiri 1, Mohammad Bokaeian 2, Mehdi Hassanshahian 3 *

1 Department of Agronomy and Plant Breeding, Agriculture Research Center, Zabol University, Zabol, IR Iran
2 Infectious Diseases and Tropical Medicine Research Center,Zahedan University of Medical Science, Zabol, IR Iran
3 Department of Biology, Faculty of Science, ShahidBahonar University of Kerman, Kerman, IR Iran
*Corresponding author: Mehdi Hassanshahian, Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, IR Iran. Tel: +98-9132906971, Fax: +98- 3413222032, Email: hasanshahi@gmail.com

Abstract

Background: Development of resistance to many of the commonly used antibiotics is an impetus for further attempts to search for new antimicrobial agents.

Objectives: In the present study, the antibacterial activity of Saturejahortensis essential oil against multi-drug resistant bacteria isolated from the urinary tract infections was investigated.

Materials and Methods: During the years 2011 to 2012 a total of 36 strains of pathogenic bacteria including 12 Klebsiellapneumoniae, 12 Escherichia coli and 12 Staphylococcus aureus species were isolated from urine samples of hospitalized patients (Amir Al-Momenin Hospital, Zabol, South-eastern Iran) suffering from urinary tract infections. After bacteriological confirmatory tests, the minimum inhibitory concentrations of the essential oil of Saturejahortensis were determined using micro-dilution method.

Results: The antibiotic resistance profile of the E. coli isolates were as follows: ceftazidime (50%) cefixime (41.6%), tetracycline (75%), erythromycin (58.3%). However K. pneumoniae isolates showed resistance to ceftazidime (33.3%), cefixime (58.3%), erythromycin (75%) and S. aureus isolates were resistant to cefixime (33.3%), trimethoprim-sulfamethoxazole (41.66%), penicillin (50%), oxacillin (83.3%), ceftazidime (66.6%) and vancomycin (8.3%). The essential oil of this plant had inhibitory effect against most isolates. More than 1/3 of the E. coli isolates showed the lowest MIC (10 ppm) whereas more than 1/3 of the K. pneumoniae isolates showed the highest (250 ppm) MIC values. In contrast ,equal number of S. aureus isolates showed the low MIC values (10 and 50 ppm), while the heighest MIC (250 ppm) was seen in 1/3 of isolates and moderate MIC (100 ppm) was seen in one isolate only.

Conclusions: The Saturejahortensis essential oil has a potent antimicrobial activity against multi-drug resistant bacteria. The present study confirms the usefullness of this essential oil as antibacterial agent but further research is required to evaluate the practical value of this plant before proving its therapeutic applications.

Implication for health policy/practice/research/medical education:

Antimicrobial agents are important for treatment of infection diseases.

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