Submitted: 26 Mar 2018
Revised: 14 Aug 2018
Accepted: 19 Aug 2018
First published online: 24 Aug 2018
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Int J Enteric Pathog. 2018;6(3):56-59.
doi: 10.15171/ijep.2018.16
  Abstract View: 93
  PDF Download: 74

Original Article

Seroprevalence of Anti-Helicobacter pylori and Anti-CagA IgG Antibodies in Iranian Dyspeptic Patients

Sadegh Afzali 1,2, Ali Mandegary 1,3, Mojtaba Alimolaei 2 * ORCiD, Mahmoud-Reza Heidari 1,4

1 Department of Toxicology and Pharmacology, School of Pharmacy, Kerman University of Medical SciencesDepartment of Toxicology and Pharmacology, School of Pharmacy, Kerman University of Medical Sciences
2 Department of Research and Technology, Kerman branch, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Kerman, Iran
3 Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
4 Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran


Background: Helicobacter pylori, a worldwide infection, is associated with several infectious diseases including gastric ulcer, peptic ulcer, and gastric cancer resulting from the cytotoxinassociated gene A (CagA). The purpose of this study was to evaluate the seroprevalence of anti-H. pylori and anti-CagA IgG antibodies in Iranian dyspeptic patients.

Methods: In this prospective epidemiological survey, a total of 659 patients were evaluated for the presence of general anti-H. pylori IgG, and then for anti-CagA IgG by two commercial ELISA kits.

Results: The prevalence of general anti-H. pylori IgG was 58.1% (383 of 659 patients) which increased progressively with age (P<0.05) and was not significantly influenced by the sex (P=0.08). The prevalence of anti-CagA IgG antibody in seropositive and seronegative patients for general H. pylori IgG was 52.9% (37 of 70) and 61.9% (13 of 21), respectively.

Conclusion: This is the first report on the high prevalence of anti-CagA IgG in both seropositive and seronegative patients for general IgG, indicating the importance of this antibody in diagnosis of H. pylori positive patients after seroconversion of the general IgG.

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