Submitted: 03 Feb 2018
Revised: 09 Aug 2018
Accepted: 15 Aug 2018
First published online: 26 Aug 2018
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Int J Enteric Pathog. 2018;6(3):60-64.
doi: 10.15171/ijep.2018.17
  Abstract View: 86
  PDF Download: 63

Research Article

Tetracycline Resistance Genes in Salmonella enterica Serovars With Animal and Human Origin

Rahem Khoshbakht 1 * ORCiD, Abdollah Derakhshandeh 2, Leila Jelviz 3, Fatemeh Azhdari 3

1 Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
2 Department of Ppathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
3 Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
Corresponding Author: Rahem Khoshbakht DVM, Ph.D in Bacteriology; Assistant Professor, Faculty of Veterinary Medicine, Amol, Iran. Tel: +989113919059 Fax: +981144271054 Email: r.khoshbakht@ausmt.ac.ir Email: khoshbakht.r@gmail.com

Abstract

Background: Tetracycline is one of the important antibacterial agents which is used against various bacterial infections. Different bacterial species and strains convey various tetracycline resistance (tetr ) genes. Objective: The present study was conducted to evaluate the occurrence of five tetr genes (tetA, tetB, tetC, tetD, and tetM) among Salmonella serovars obtained from humans and animals.

Materials and Methods: A total of 60 different Salmonella strains previously recovered from humans, poultry, and animals were subjected to polymerase chain reaction (PCR) and sequence analysis of the genes.

Results: In total, 6 strains were positive for the presence of tetA gene; three serotypes were also positive for the presence of tetC gene. The sequence analysis and phylogenetic tree showed similarities between the sequences of serovars in the present study and other Salmonella serovars and some other bacteria species in GenBank data.

Conclusion: The results showed the great distribution of tetracycline resistance genes among Salmonella serovars with different sources which could be the effect of widespread use of the antibiotic particularly in the animals breeding farms.

 
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