Submitted: 15 Oct 2017
Revised: 21 Jan 2018
Accepted: 22 Apr 2018
First published online: 27 May 2018
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Int J Enteric Pathog. 2018;6(3):75-78.
doi: 10.15171/ijep.2018.20
  Abstract View: 226
  PDF Download: 175

Research Article

Antimicrobial Features of Cerastoderma and Didacna Double Basins Peptides 

Abdolmajid Ghasemian 1,2 ORCiD, Farshad Nojoomi, Zahra Najafi-olya, Hassan Rajabi-Vardanjani * , Hossein Rajabi-Vardanjani 4 *

1 Department of Microbiology, Fasa University of Medical Sciences, Fasa, Iran
2 Microbiology Department, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
3 Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4 Researcher of Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: Hassan Rajabi-Vardanjani, Tel: +989394514860; Fax:+9882884555; Email: Email:


Background: In recent years, high attention has been given to the biological activities of natural compounds and their potential antimicrobial properties.

Objective: In this study, the antibacterial properties of the extracts from tissue and peptides of Cerastoderma and Didacna were studied.

Materials and Methods: samples of Cerastoderma and Didacna were collected and washed. Then, the soft tissues were cut and powdered, and concentrations of 16, 8, 4, 2, 1 and 0.5 of chloroform, ethanol and methanol, and in addition extract of enzymatic hydrolysis were prepared, and their antibacterial activities against Staphylococcus aureus, Escherichia coli and Salmonella paratyphi were investigated. The disc diffusion method was used for the evaluation of strains susceptibility. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were investigated for bacterial growth inhibition.

Results: Methanolic and ethanolic extracts from Cerastoderma demonstrated higher growth inhibitory effects compared to those from Didacna on E. coli and S. paratyphi and exhibited similar activities against S. aureus at concentrations 16 and 8 ug/mL. In addition, chloroform extracts of Cerastoderma and Didacna displayed similar inhibitory effects on S. paratyphi and S. aureus at concentrations 16 and 8 ug/mL which was a suitable effect, and the extract from Cerastoderma was more effective. MIC and MBC of methanolic extracts were at the lowest level, especially against S. aureus.

Conclusion: It was revealed that Cerastoderma and Didacna extracts were effective as antibacterial compounds on S. aureus, E. coli and S. paratyphi species as natural agents.

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