Submitted: 12 Feb 2017
Revised: 01 Mar 2017
Accepted: 04 Mar 2017
First published online: 06 Mar 2017
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Int J Enteric Pathog. 2017;5(1):5-8.
doi: 10.15171/ijep.2017.02
  Abstract View: 187
  PDF Download: 211
  Full Text View: 202

Research Article

In Vitro Assessment of the Protoscolicidal Activities of the Ephedra major Methanol Extracts

Mohammad Zibaei 1, Sepideh Salehi 2 * , Zohreh Jafari 2, Saeed Bahadory 1, Farzaneh Firoozeh 3, Mehdi Shahivand 2

1 Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2 Department of Biology, Arak Branch, Islamic Azad University, Arak, Iran
3 Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Abstract

Background: The basic approaches for the treatment of human hydatidosis are surgery and chemotherapy. The risk of spillage of protoscoleces cannot be underestimated during surgery.
Objectives: This study aimed to evaluate the scolicidal activity of Ephedra major methanol extracts against protoscoleces of hydatid cysts.
Materials and Methods: Various concentrations of the methanolic extracts (0.01%-0.001%, mg/mL) of different parts of E. major were used for exposure times of 10, 20, 30, and 60 minutes.
Results: Different extracts of E. major were tested, 0.1% concentration had strong scolicidal activity in 60 minutes. The stem extracts of 0.1% had very strong scolicidal effects in 60 minutes of exposure time and the mortality rate decreased with the lower concentration.
Conclusion: Findings showed that scolicidal effects of E. major root extracts against cystic echinococcosis protoscoleces were less effective, while the stem and leaf extracts demonstrated more activities, respectively.
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