Submitted: 16 Mar 2016
Revised: 25 Apr 2016
Accepted: 28 Apr 2016
First published online: 15 May 2016
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Int J Enteric Pathog. 2016;4(3): e37902.
doi: 10.15171/ijep.2016.07
  Abstract View: 556
  PDF Download: 386
  Full Text View: 320

Original Article

Presence of the Helicobacter pylori in Esophageal Squamous Cell Carcinoma Samples

Aynaz Khademian 1, Ramazan Rajabnia 2, Elaheh Ferdosi-Shahandashti 3, Soraya Khafri 4, Javad Shokri Shirvani 5, Farzin Sadeghi 6, Yousef Yahyapour 2 *

1 MSc Student in Medical Microbiology, Students Research Committee, Babol University of Medical Sciences, Babol, Iran
2 Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran
3 Department of Advanced Technology in Medical Biotechnology, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Biostatistics and Epidemiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
5 Department of Internal Medicine, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
6 Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
*Corresponding Author: Yousef Yahyapour, Tel: +98-1132196476; Email:


Background: The main causes of esophageal squamous cell carcinoma (ESCC) in developing countries differ from developed countries. In developing countries, approximately onefourth of cancer cases are caused by infectious agents. In terms of infectious etiology of esophageal cancer, Helicobacter pylori has been among the most widely investigated, but its role in etiology of ESCC remains unclear.

Objectives: The present study aimed to investigate the presence of H. pylori in the pathogenesis of ESCC.

Materials and Methods: In total, 277 formalin-fixed paraffin-embedded esophageal samples (177 with ESCC, and 107 without esophageal malignancy) were examined for H. pylori infection. After removing of paraffin from tissue samples, DNA was extracted and polymerase chain reaction (PCR) was performed to investigate the presence of H. pylori.

Results: H. pylori was not detected in any of the cancerous and non-cancerous esophageal sample.

Conclusion: In the present study, there was no association between H. pylori and ESCC.

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