Submitted: 19 Aug 2014
Revised: 03 Oct 2014
Accepted: 18 Oct 2014
First published online: 06 Oct 2016
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Int J Enteric Pathog. 2015;3(2): e22930.
doi: 10.17795/ijep22930
  Abstract View: 467
  PDF Download: 321

Research Article

Retrospective Study on the Prevalence and Antibiotic Resistance Pattern of Staphylococcus Aureus and Staphylococcus Epidermidis Among Patients Suspicious of Bacteremia During 2006 - 2011

Mohammad Ali Mohaghegh 1, Kiarash Ghazvini 2, Rasool Jafari 1, Mohammad Yousef Alikhani 3, Marzieh Safari 4, Gholam Ali Azari Garamjan 2, Jamal Falahi 2, Davod Bordbar 2 *

1 Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
2 Department of Microbiology and Virology, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
4 Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
*Corresponding author: Davod Bordbar, Department of Microbiology and Virology, Mashhad University of Medical Sciences, Mashhad, IR Iran. Tel:+98-9378077542, Email: davud_bordbar@yahoo.com

Abstract

Background: Staphylococci bacteria cause different diseases, varies from mild skin infections to serious bacteremia. Also they are a major cause of nosocomial and community-acquired infections globally. Staphylococcus aureus and Staphylococcus epidermidis are the two important opportunistic pathogens of the staphylococci that both can cause bacteremia.

Objectives: The aim of the present study was to investigate the prevalence and antibiotic resistance pattern of S. aureus and S. epidermidis among blood culture of patients of Ghaem Educational, Research and Treatment Center, Mashhad, Iran, during 6 years (2006 - 2011).

Patients and Methods: In this retrospective study, hospital medical records of 28000 patients referred to Ghaem Educational, Research and Treatment Center, Mashhad, Iran, who were suspicious of blood infections during 6 years (2005-2011), were extracted. The patient’s blood culture with staphylococcal growth and their antibiogram results during 2006 - 2011 were collected and studied.

Results: Staphylococcus spp. were isolated from 600 (2.14%) out of 28000 blood cultures. Furthermore, 420 (70%), 170 (28.3%) and 10 (1.7%) out of 600 bacterial isolates identified as S. epidermidis, S. aureus and other Staphylococcus spp., respectively. Ampicillin, amoxicillin, cefixime, ceftazidime, penicillin, oxacillin, nalidixic acid and cephepime were the most antibiotics that the isolates were resistant against. Also vancommycin and chloramphenicol were the most effective antibiotics against S. epidermidis and S. aureus, respectively.

Conclusions: Prevalence of Staphylococcal bacteremia caused by S. epidermidis is fairly high comparing to S. aureus among patients referred to Ghaem Educational, Research and Treatment Center, Mashhad, Iran. Also the resistance rate of Staphylococcus spp. isolated from blood against commonly used antibiotic is high, but there are some highly sensitive antibiotic against the infection.

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