Submitted: 23 Aug 2013
Revised: 25 Aug 2013
Accepted: 31 Aug 2013
First published online: 05 Oct 2016
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Int J Enteric Pathog. 2013;1(2): e13774.
doi: 10.17795/ijep13774
  Abstract View: 353
  PDF Download: 264

Case Report

First CTX-M type ß–lactamase-Producing and Ciprofloxacin Resistant Salmonella Infection Acquired by a Child in IRAN

Farzaneh Firoozeh 1, Fereshteh Shahcheraghi 2 * , Taghi Zahraei-Salehi 3, Mohammad Mehdi Aslani 2, Reihaneh Banisaeed 3

1 Department of Microbiology and Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, IR Iran
2 Department of Microbiology and Microbiology Research Center, Pasteur Institute, Tehran, IR Iran
3 Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, IR Iran
Corresponding author: Fereshteh Shahcheraghi, Department of Microbiology and Microbiology Research Center, Pasteur Institute, Tehran, IR Iran. Tel: +98-2166405535, Fax: +98- 2166405535, Email: shahcheraghifereshteh@yahoo.com

Abstract

The frequency of multidrug-resistance (MDR) among Salmonella isolates has increased dramatically. Here we report the first case of CTX-M type ß–lactamase producing ciprofloxacin-resistant Salmonella infection as a child in Iran. Antimicrobial resistance profile was determine daccording to the Clinical and Laboratory Standards Institute. A double disk synergy test was used in the production of extended-spectrum β-lactamases (ESBLs). PCR assays were carried out to detect blaTEM, blaSHV and blaCTX-M beta lactamase genes. The presence of class 1 integrons was investigated by PCR assays. The Salmonella Enteritidis isolate from the child was ciprofloxacin and extended-spectrum cephalosporins resistant and found to carry the blaCTX-M beta-lactamase gene and class 1 integrons, suggests that antimicrobial resistance determinants may be located on the same genetic unit of the class 1 integrons identified here. Resistance to ciprofloxacin and extended spectrumcephalosporins, the drugs of choice for treating invasive salmonellosis, especially in children is a public health problem.

Implication for health policy/practice/research/medical education:

In the present study, we described the first report of ciprofloxacin resistant Salmonella infection acquired by a child in Iran.

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